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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDKL5 All Species: 0.91
Human Site: S324 Identified Species: 2.5
UniProt: O76039 Number Species: 8
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O76039 NP_001032420.1 1030 115538 S324 H V E S S T L S N R N Q A G K
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta NP_001129485 570 64691
Dog Lupus familis XP_548881 960 107395 K275 S V L L D L M K N L L K L D P
Cat Felis silvestris
Mouse Mus musculus Q3UTQ8 938 105471 S257 P A V N H P Q S L E R R Y L G
Rat Rattus norvegicus Q5XIT0 507 57117
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514328 967 107039 K275 G V L L D L M K N L L K L D P
Chicken Gallus gallus XP_425571 960 107495 N276 V L L D L M K N L L K L D P A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001124243 1039 116666 C348 R R A N S K D C S S L P R H E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796071 627 72401
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 26.7 88.1 N.A. 85.9 23.6 N.A. 76.5 75.2 N.A. 55.3 N.A. N.A. N.A. N.A. 25.5
Protein Similarity: 100 N.A. 39.5 89.7 N.A. 88.9 36.5 N.A. 82.5 83.6 N.A. 69.1 N.A. N.A. N.A. N.A. 39
P-Site Identity: 100 N.A. 0 13.3 N.A. 6.6 0 N.A. 13.3 0 N.A. 6.6 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 N.A. 0 26.6 N.A. 20 0 N.A. 26.6 13.3 N.A. 26.6 N.A. N.A. N.A. N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 12 12 0 0 0 0 0 0 0 0 0 12 0 12 % A
% Cys: 0 0 0 0 0 0 0 12 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 12 23 0 12 0 0 0 0 0 12 23 0 % D
% Glu: 0 0 12 0 0 0 0 0 0 12 0 0 0 0 12 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 12 0 0 0 0 0 0 0 0 0 0 0 0 12 12 % G
% His: 12 0 0 0 12 0 0 0 0 0 0 0 0 12 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 12 12 23 0 0 12 23 0 0 12 % K
% Leu: 0 12 34 23 12 23 12 0 23 34 34 12 23 12 0 % L
% Met: 0 0 0 0 0 12 23 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 23 0 0 0 12 34 0 12 0 0 0 0 % N
% Pro: 12 0 0 0 0 12 0 0 0 0 0 12 0 12 23 % P
% Gln: 0 0 0 0 0 0 12 0 0 0 0 12 0 0 0 % Q
% Arg: 12 12 0 0 0 0 0 0 0 12 12 12 12 0 0 % R
% Ser: 12 0 0 12 23 0 0 23 12 12 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 12 0 0 0 0 0 0 0 0 0 % T
% Val: 12 34 12 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 12 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _